While Merck is wrapping up a series of clinical trials of diet drug Taranabant, which it expects to submit for FDA approval later this year, Pfizer has just launched a new Phase III trial of its diet drug CP-945,598, suggesting it may be considerably further away from being brought to market.
Merck has two Phase III trials –one a two-year Phase III study involving 2,400 patients, the second a one-year Phase III study involving 1,000 patients — of taranabant, a CB-1 receptor inverse agonist, that appear to have been completed in the first two months of this year.
To this point, Merck has provided no information on the results of these studies — and for that matter, still has released no final information from a two-year, 2,400-patient Phase II study that was completed in December.
Meanwhile, Pfizer’s clinical trial program for its drug targeting the same receptor — which unlike taranabant, is a CB-1 receptor antagonist like rimonabant (Acomplia) — appears to be lagging significantly behind.
Pfizer seems to still be recruiting participants for its two-year Phase III study of CP-945,598 — which began back in 2006 — and lists the estimated completion date for this study as August 2009.
Moreover, Pfizer has only recently begun recruiting 850 participants for a one-year Phase III trial of CP-945,598 — which like the Merck one-year trial of taranabant is focused not on weight-loss but on the use of the drug to prevent weight-regain — and this trial is not set for completion until Jan. 2010.
The notoriously close-mouthed Pfizer also has provided no information on results of its earlier Phase II study of CP-945,598, which was completed more than two years ago.
Interestingly, however, both Merck and Pfizer have one-year Phase III studies underway of the use of their CB-1 drugs in treating type 2 diabetics.
The treatment of diabetes as well as obesity seems to be at the heart of the hopes of Sanofi-Aventis for a second try next year at U.S. approval of rimonabant. Sanofi withdrew its original application last summer after a U.S. FDA advisory panel expressed concern over the drug’s depressive side-effects.
Acomplia is an effective weight loss and anti-obesity medication. If you are among people troubled by obesity, then unravelling some facts about Rimonabant on the internet will surely help you to buy Acomplia online. You may be curious to know about Rimonabant, which is an active ingredient of Acomplia, side effects of Acomplia, and dosage of Acomplia.
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It was French pharmaceutical company, Sanofi-Aventis, which manufactured this anti-obesity drug. Health experts are of the view that Acomplia works efficiently to block receptors in the brain that help to increase your hunger.
You may observe mild side effects of Acomplia. These side effects of Acomplia are easily treatable after taking medical help. The doctor can easily suggest some other useful medication or reduce the dosage of Acomplia.
Acomplia is available both in capsule and tablet form. Sometimes, over dosage of Acomplia can result in harmful side effects. So, follow your doctor’s advice about dosage of Acomplia as it very necessary.
Acomplia (Rimonabant) - Effective weight loss and anti-obesity medication
The doctors started prescribing Acomplia to the patients in the UK in June 2006. It is an effective weight loss and anti-obesity medication. Health experts endorse the fact about Rimonabant that it can stop people from over-eating and help them to shed off extra fats. This may come as a relief to all the obese people throughout the world as obesity has become a major health issue of the 21st century.
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Facts about Rimonabant
- A French pharmaceutical company named Sanofi-Aventis manufactured this oral prescription anti-obesity. You might know that Rimonabant is sold in the market under the brand name of Acomplia
- It works in the body by blocking CB-1 (Cannabinoid) receptors that send signal of hunger to the brain. Health experts reveal about Rimonabant that it works efficiently to block these receptors in a unique way
- Health experts also opine about Rimonabant that it works to improve cardiovascular risk factors such as triglyceride, HDL, insulin tolerance, and even smoking cessation
- The most important fact about Rimonabant is that this drug not only helps in weight loss but also maintains the condition of weight loss
- Statistics reveal about Rimonabant that success rate of this drug is quite high in comparison to other anti-obesity drugs in the market
Side effects of Acomplia
It is quite common to observe side effects of Acomplia among its users. This is not only true about Rimonabant but every prescription drug has its share of side effects. However, these side effects are usually mild and are easily treatable if you take medical care.
The most common side effects of Acomplia include dizziness, headache, upset stomach, nausea, and muscle pain. However, your doctor can suggest you other useful medication or reduce the dosage of Acomplia. This can help to treat these side effects of Acomplia.
Dosage of acomplia
Acomplia is available in both capsule and tablet form. It is ideal to take 20mg capsule before breakfast or an hour or two afterwards. You can repeat the same for tablets also. However, your doctor may also divide the dosage of Acomplia to half a tablet twice daily instead of full capsule in a day as per your need. You should not chew or crush tablets but rather swallow the whole with a large glass of water.
People who are above 60 years of age or below 18 years should consult a doctor who might adjust the dosage of Acomplia for them to prescribe it to them. Over dosage of Acomplia can also result in harmful side effects. Therefore, you should always take dosage of Acomplia according to your doctor’s recommendation.
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