While Merck is wrapping up a series of clinical trials of diet drug Taranabant, which it expects to submit for FDA approval later this year, Pfizer has just launched a new Phase III trial of its diet drug CP-945,598, suggesting it may be considerably further away from being brought to market.
Merck has two Phase III trials –one a two-year Phase III study involving 2,400 patients, the second a one-year Phase III study involving 1,000 patients — of taranabant, a CB-1 receptor inverse agonist, that appear to have been completed in the first two months of this year.
To this point, Merck has provided no information on the results of these studies — and for that matter, still has released no final information from a two-year, 2,400-patient Phase II study that was completed in December.
Meanwhile, Pfizer’s clinical trial program for its drug targeting the same receptor — which unlike taranabant, is a CB-1 receptor antagonist like rimonabant (Acomplia) — appears to be lagging significantly behind.
Pfizer seems to still be recruiting participants for its two-year Phase III study of CP-945,598 — which began back in 2006 — and lists the estimated completion date for this study as August 2009.
Moreover, Pfizer has only recently begun recruiting 850 participants for a one-year Phase III trial of CP-945,598 — which like the Merck one-year trial of taranabant is focused not on weight-loss but on the use of the drug to prevent weight-regain — and this trial is not set for completion until Jan. 2010.
The notoriously close-mouthed Pfizer also has provided no information on results of its earlier Phase II study of CP-945,598, which was completed more than two years ago.
Interestingly, however, both Merck and Pfizer have one-year Phase III studies underway of the use of their CB-1 drugs in treating type 2 diabetics.
The treatment of diabetes as well as obesity seems to be at the heart of the hopes of Sanofi-Aventis for a second try next year at U.S. approval of rimonabant. Sanofi withdrew its original application last summer after a U.S. FDA advisory panel expressed concern over the drug’s depressive side-effects.
Acomplia is an effective weight loss and anti-obesity medication. If you are among people troubled by obesity, then unravelling some facts about Rimonabant on the internet will surely help you to buy Acomplia online. You may be curious to know about Rimonabant, which is an active ingredient of Acomplia, side effects of Acomplia, and dosage of Acomplia.
Many websites sell Acomplia online. You can select the one that has reputation in the market. In addition, you should also collect testimonials of users who buy Acomplia online from that website.
It was French pharmaceutical company, Sanofi-Aventis, which manufactured this anti-obesity drug. Health experts are of the view that Acomplia works efficiently to block receptors in the brain that help to increase your hunger.
You may observe mild side effects of Acomplia. These side effects of Acomplia are easily treatable after taking medical help. The doctor can easily suggest some other useful medication or reduce the dosage of Acomplia.
Acomplia is available both in capsule and tablet form. Sometimes, over dosage of Acomplia can result in harmful side effects. So, follow your doctor’s advice about dosage of Acomplia as it very necessary.
Acomplia (Rimonabant) - Effective weight loss and anti-obesity medication
The doctors started prescribing Acomplia to the patients in the UK in June 2006. It is an effective weight loss and anti-obesity medication. Health experts endorse the fact about Rimonabant that it can stop people from over-eating and help them to shed off extra fats. This may come as a relief to all the obese people throughout the world as obesity has become a major health issue of the 21st century.
If you are among people troubled by obesity, then getting some facts about Rimonabant on the internet will surely help you to buy Acomplia online. Many questions may crop up in your mind about Rimonabant. What are side effects of Acomplia if I take it? What should be dosage of Acomplia? Shall I buy Acomplia online or from a local pharmacy? You can continue reading this article to find answers to your questions.
Facts about Rimonabant
- A French pharmaceutical company named Sanofi-Aventis manufactured this oral prescription anti-obesity. You might know that Rimonabant is sold in the market under the brand name of Acomplia
- It works in the body by blocking CB-1 (Cannabinoid) receptors that send signal of hunger to the brain. Health experts reveal about Rimonabant that it works efficiently to block these receptors in a unique way
- Health experts also opine about Rimonabant that it works to improve cardiovascular risk factors such as triglyceride, HDL, insulin tolerance, and even smoking cessation
- The most important fact about Rimonabant is that this drug not only helps in weight loss but also maintains the condition of weight loss
- Statistics reveal about Rimonabant that success rate of this drug is quite high in comparison to other anti-obesity drugs in the market
Side effects of Acomplia
It is quite common to observe side effects of Acomplia among its users. This is not only true about Rimonabant but every prescription drug has its share of side effects. However, these side effects are usually mild and are easily treatable if you take medical care.
The most common side effects of Acomplia include dizziness, headache, upset stomach, nausea, and muscle pain. However, your doctor can suggest you other useful medication or reduce the dosage of Acomplia. This can help to treat these side effects of Acomplia.
Dosage of acomplia
Acomplia is available in both capsule and tablet form. It is ideal to take 20mg capsule before breakfast or an hour or two afterwards. You can repeat the same for tablets also. However, your doctor may also divide the dosage of Acomplia to half a tablet twice daily instead of full capsule in a day as per your need. You should not chew or crush tablets but rather swallow the whole with a large glass of water.
People who are above 60 years of age or below 18 years should consult a doctor who might adjust the dosage of Acomplia for them to prescribe it to them. Over dosage of Acomplia can also result in harmful side effects. Therefore, you should always take dosage of Acomplia according to your doctor’s recommendation.
Now after clearing your doubts, you can Buy acomplia online. You can choose other methods but the process to buy Acomplia online is quite simple. It saves your lot of time and energy. You can also research about Rimonabant, side effects of Acomplia, and dosage of Acomplia on the internet. So that you can buy Acomplia online and it is an effective weight loss and anti-obesity medication.
With sales of Acomplia (rimonabant) is low in the several dozen countries where it is on the market, Sanofi-Aventis executives had little to say about their pioneering obesity treatment in a report to analysts on Feb. . But that hardly means they have given up on the CB-1 receptor antagonist.
Instead, Sanofi unveiled plans to make at least three presentations at major U.S. and European medical meetings during 2008 on the results of clinical trials of Acomplia as a treatment for heart disease and diabetes.
And as a strong indication that the results Sanofi Aventis is seeing from the diabetes trials continue to look really good, the French company reiterated that it plans to seek for FDA approval of rimonabant (to be called Zimulti in the United States), this time for treatment of diabetes, in 2009.
So where do things stand on the hopes of millions of obese and overweight people that rimonabant would become the next blockbuster pill for treatment of obesity?
Well, Sanofi reported that fourth quarter sales of Acomplia worldwide totaled 21 million Euros (approximately US $30.6 million) — unchanged from the 21 million Euros in sales that Sanofi reported for the third quarter of 2007.
He said results of the ARPEGGIO study, evaluating rimonabant in combination with insulin for treatment of diabetes, will be presented to the American Diabetes Association at its annual meeting in June 2008.
Cluzel also said Sanofi is awaiting further recommendations from the FDA on the tracking during clinical trials of depressive side-effects associated with rimonabant — the problem that led in mid-2007 to Sanofi’s withdrawal of its application to have Zimulti approved for sale as an obesity drug in the U.S.
“As for side effects, we are in conformity with FDA recommendations particularly when it comes to psychiatric effects, suicidal ideas are very much in the limelight, and of course, this applies for the whole class of CB1s as well as for antiepileptic pills and antidepressives as a class,” Cluzel declared.
“So we are waiting to see what the FDA recommendations will be,” he also said.
So Acomplia will be on the american market sooner or later as an weight loss pill or as a pill that treats diabetes.Will hope that happens really soon because millions of people need it!
Learn to love your body and if you are really serious about your body then you even in dreams don’t want those extra kilos of unwanted fat to present on it. Well people adopt numerous methods like starving and exercising to shed off their excess fats and overcome overweight as well. But its also true that majority of them fail to achieve the desired results. In vain they become either depressed or suffer in anxiety. They see no ways to end their woes.
Burning of weight is not an easy task. Besides maintaing a balanced diet and exercise daily is not an easy affair for everybody. There are certain obligations which may come in the way of their daily life schedule and this may hamper their daily weight loss journey. But choice of effective weight loss medication like Rimonabant along with well planned weight loss program can be very beneficial. One such drug or diet pill that can be very effective is Rimonabant. This drug is well approved by the US FDA as an anti obesity diet pill which comes with success record that assures obese patients to loose significant amount of weight and keep them free from fats.
Rimonabant is a weight loss drug which belongs to the class of anorectics which acts on the central nervous system to inhibit the hunger centre and hence suppresses the appetite .It is recommended that Rimonabant should be used for short-term, normally up to 12 weeks while following non- pharmacological approaches to weight loss such as healthy dieting and exercise.
It’s a prescription diet pill and only the doctor can determine the right amount of dose for a particular individual. Generally three doses above 120 mg after 30 mins of every meal are what a doctor suggests. But depending on your obesity situation, the doses may change. First timers may suffer from bowel changes like gas with oily discharge, inability to control your bowel movements, constipation, and indigestion. But no major side affects has been recorded till date. Pregnant women must go for a doctor consultation before taking Rimonabant.
Maintaining a healthy eating plan with a routine exercise in conjunction with Rimonabant will lead you to a fat free life.
Unfortunately many people accumulate excess amount of fats in their body than required. This is a serious problem as it can lead to various chronic diseases like heart troubles, high blood pressure and diabetes. Obesity is indeed a serious problem affecting majority around the world. As a solution for this problem, a panel of independent dieticians developed a unique diet pill for ruling obesity, way back in 1959. This diet pill known as Rimonabant is completely dedicated to weight loss. Rimonabant is recommended for people that have a body mass index (BMI) of 28 or more. It is only intended for those with major weight problems.
There are genuine results that will amaze you by its miracle. It kills your hunger by suppressing the appetite. Of late it’s the most common prescribed appetite suppressant. It is readily available in tablets and also sold under the brand names Slimona, Rimoslim and Obitone. It is also available as Rimonabant.
Rimonabant works by stimulating the hypothalamus gland in the brain and affects certain neurotransmitters to decrease appetite. It is generally taken in empty stomach or just before breakfast. Studies revealed that Rimonabant in combination with a balanced diet and a bit of jogging helps a lot to loose weight in the long run.
As the drug affects our brain it can cause sleep disorders. Apart from this other side affects are stomach upset, dry mouth and constipation are common. But as the body gets become accustomed with this diet pill, every thing becomes normal again.
The chief constituent Hydrochloride is a very active substance. Apart from killing our appetite, it increases the heart beat and blood pressure. So heart patients should consult a doctor for its proper use.
Coming in various colours and strengths Rimonabant diet Pills are prescription drug and especially used for short term management or treatment of obesity. Prolonged usage may form a daily habit. So for the appropriate dose and skip its side affects safely, consulting a doctor is a must.
